Submission Date: Aug 31, 2016
Summary: Expression profiling comparing healthy kidneys of wild-type FVB mice and wild-type full congenic FVB-HIVAN1CAST mice
HIV-1 transgenic mice on the FVB/NJ background (TgFVB) represent a validated model of HIV-associated nephropathy (HIVAN). A major susceptibility locus, HIVAN1, was previously mapped to chromosome 3A1-A3 in a cross between TgFVB and CAST/EiJ (CAST) strains, and introgression of a 51.9 Mb segment encompassing HIVAN1 from CAST into TgFVB results in accelerated development of nephropathy. We performed genome-wide expression profiling of whole kidneys from wild-type (without the HIV-1 transgene) full congenic FVB-HIVAN1CAST and FVB mouse strains, with the goal of identifying genes with differential renal expression in the HIVAN1 locus that may be associated with the development of nephropathy upon exposure to HIV-1. We only profiled healthy wild-type kidneys because the profound histopathological lesions of HIV-1 transgenic mice introduce many secondary gene expression changes that can confound interpretation of transcriptomic data.
GEO Accession ID: GSE86269
PMID: No Pubmed ID
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| GROUP | CONDITION | SAMPLES |
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GSM2299222 GSM2299223 GSM2299224 GSM2299225 GSM2299226 GSM2299227 GSM2299228 GSM2299229 GSM2299230 GSM2299231 GSM2299232 GSM2299233 GSM2299234 GSM2299235 GSM2299236 GSM2299240 GSM2299243 GSM2299245 GSM2299247
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GSM2299202 GSM2299203 GSM2299204 GSM2299205 GSM2299206 GSM2299207 GSM2299208 GSM2299209 GSM2299210 GSM2299211 GSM2299212 GSM2299213 GSM2299214 GSM2299215 GSM2299216 GSM2299217 GSM2299218 GSM2299219 GSM2299220 GSM2299221
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Submission Date: Aug 31, 2016
Summary: Expression profiling comparing healthy kidneys of wild-type FVB mice and wild-type full congenic FVB-HIVAN1CAST mice
HIV-1 transgenic mice on the FVB/NJ background (TgFVB) represent a validated model of HIV-associated nephropathy (HIVAN). A major susceptibility locus, HIVAN1, was previously mapped to chromosome 3A1-A3 in a cross between TgFVB and CAST/EiJ (CAST) strains, and introgression of a 51.9 Mb segment encompassing HIVAN1 from CAST into TgFVB results in accelerated development of nephropathy. We performed genome-wide expression profiling of whole kidneys from wild-type (without the HIV-1 transgene) full congenic FVB-HIVAN1CAST and FVB mouse strains, with the goal of identifying genes with differential renal expression in the HIVAN1 locus that may be associated with the development of nephropathy upon exposure to HIV-1. We only profiled healthy wild-type kidneys because the profound histopathological lesions of HIV-1 transgenic mice introduce many secondary gene expression changes that can confound interpretation of transcriptomic data.
GEO Accession ID: GSE86269
PMID: No Pubmed ID
Control Condition
Perturbation Condition