GSE183822: Altered pattern of circulating miRNAs in HIV lipodystrophy perturbs key adipose differentiation and inflammation pathways

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Description

Submission Date: Sep 09, 2021

Summary: We identified a microRNA (miRNA) profile characterizing HIV lipodystrophy and explored the downstream mechanistic implications with respect to adipocyte biology and the associated clinical phenotype. Human preadipocytes transfected with mimic miR-20a-3p, anti–miR-324-5p, or anti–miR-186 induced consistent changes in latent transforming growth factor beta binding protein 2 (Ltbp2), Wisp2, and Nebl expression.

GEO Accession ID: GSE183822

PMID: 34383714

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GROUP CONDITION SAMPLES
adipocytes
GSM5571791 GSM5571792 GSM5571793 GSM5571794
GSM5571783 GSM5571784 GSM5571785 GSM5571786
GSM5571787 GSM5571788 GSM5571789 GSM5571790
GSM5571795 GSM5571796 GSM5571797 GSM5571798
Description

Submission Date: Sep 09, 2021

Summary: We identified a microRNA (miRNA) profile characterizing HIV lipodystrophy and explored the downstream mechanistic implications with respect to adipocyte biology and the associated clinical phenotype. Human preadipocytes transfected with mimic miR-20a-3p, anti–miR-324-5p, or anti–miR-186 induced consistent changes in latent transforming growth factor beta binding protein 2 (Ltbp2), Wisp2, and Nebl expression.

GEO Accession ID: GSE183822

PMID: 34383714

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Differential Gene Expression Analysis
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Bulk RNA-seq Appyter

This pipeline enables you to analyze and visualize your bulk RNA sequencing datasets with an array of downstream analysis and visualization tools. The pipeline includes: PCA analysis, Clustergrammer interactive heatmap, library size analysis, differential gene expression analysis, enrichment analysis, and L1000 small molecule search.