GSE168407: A follicular regulatory innate lymphoid cell population impairs interactions between germinal center Tfh and B cells

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Description

Submission Date: Mar 07, 2021

Summary: Here we show a newly identified human Innate Lymphoid Cell population present in the follicles of tonsils and lymph nodes termed follicular regulatory ILCs (ILCFR). ILCFR have a distinct phenotype and transcriptional program when compared to other defined ILCs. Surprisingly, ILCFR inhibit the ability of follicular helper T (Tfh) cells to provide B cell help. The localization of ILCFR to the germinal centers suggests these cells may interfere with germinal center B cell (GC-B) and germinal center Tfh cell (GC-Tfh) interactions through the production of transforming growth factor beta (TGF-b). Intriguingly, under conditions of impaired GC-Tfh-GC-B cell interactions, such as human immunodeficiency virus (HIV) infection, the frequency of these cells is increased. Overall, we predict a role for ILCFR in regulating GC-Tfh-GC-B cell interactions and propose they expand in chronic inflammatory conditions.

GEO Accession ID: GSE168407

PMID: 33980982

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GROUP CONDITION SAMPLES
tonsil
GSM5138459 GSM5138466 GSM5138473 GSM5138480 GSM5138487 GSM5138494 GSM5138501
GSM5138460 GSM5138467 GSM5138474 GSM5138481 GSM5138488 GSM5138495 GSM5138502
GSM5138456 GSM5138463 GSM5138470 GSM5138477 GSM5138484 GSM5138491 GSM5138498
GSM5138455 GSM5138462 GSM5138469 GSM5138476 GSM5138483 GSM5138490 GSM5138497
GSM5138458 GSM5138465 GSM5138472 GSM5138479 GSM5138486 GSM5138493 GSM5138500
GSM5138454 GSM5138461 GSM5138468 GSM5138475 GSM5138482 GSM5138489 GSM5138496
GSM5138457 GSM5138464 GSM5138471 GSM5138478 GSM5138485 GSM5138492 GSM5138499
Description

Submission Date: Mar 07, 2021

Summary: Here we show a newly identified human Innate Lymphoid Cell population present in the follicles of tonsils and lymph nodes termed follicular regulatory ILCs (ILCFR). ILCFR have a distinct phenotype and transcriptional program when compared to other defined ILCs. Surprisingly, ILCFR inhibit the ability of follicular helper T (Tfh) cells to provide B cell help. The localization of ILCFR to the germinal centers suggests these cells may interfere with germinal center B cell (GC-B) and germinal center Tfh cell (GC-Tfh) interactions through the production of transforming growth factor beta (TGF-b). Intriguingly, under conditions of impaired GC-Tfh-GC-B cell interactions, such as human immunodeficiency virus (HIV) infection, the frequency of these cells is increased. Overall, we predict a role for ILCFR in regulating GC-Tfh-GC-B cell interactions and propose they expand in chronic inflammatory conditions.

GEO Accession ID: GSE168407

PMID: 33980982

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