GSE165132: HIV-exposed seronegative sex workers express high levels of regulatory T cells, low levels of T cell activation and an intact ectocervical tissue microenvironment

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Submission Date: Jan 19, 2021

Summary: Immunological correlates of natural resistance to HIV have been identified in HIV-exposed seronegative (HESN) individuals. The cervicovaginal epithelium has not been studied for such correlates despite constituting an important barrier against sexual HIV transmission. To fill this gap in knowledge, we collected samples of blood and genital mucosa from Kenyan HESN sex workers (n=29) and controls (n=33). The samples were analyzed by several methods including tissue-based RNA sequencing. A significantly higher relative proportion of regulatory T cells and lower proportion of activated cervical T cells were found in the HESN group compared with the controls. However, they had comparable tissue RNA transcriptional profiles. In conclusion, the identification of an increased proportion of regulatory T cells in blood, a lower proportion of activated cervical T cells, and an intact ectocervical microenvironment in HESN individuals add new data to current knowledge about natural resistance to sexual transmission of HIV.

GEO Accession ID: GSE165132

PMID: 33806390

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GROUP CONDITION SAMPLES
Infection
GSM5026752 GSM5026753 GSM5026754 GSM5026755 GSM5026756 GSM5026757 GSM5026758 GSM5026759 GSM5026760 GSM5026761 GSM5026762 GSM5026763 GSM5026764 GSM5026765 GSM5026766 GSM5026767 GSM5026768 GSM5026769 GSM5026770 GSM5026771 GSM5026772 GSM5026773 GSM5026774 GSM5026775 GSM5026776 GSM5026777 GSM5026778 GSM5026779
GSM5026780 GSM5026781 GSM5026782 GSM5026783 GSM5026784 GSM5026785 GSM5026786 GSM5026787 GSM5026788 GSM5026789 GSM5026790 GSM5026791 GSM5026792 GSM5026793 GSM5026794 GSM5026795 GSM5026796 GSM5026797 GSM5026798 GSM5026799 GSM5026800 GSM5026801 GSM5026802 GSM5026803 GSM5026804 GSM5026805 GSM5026806 GSM5026807
Description

Submission Date: Jan 19, 2021

Summary: Immunological correlates of natural resistance to HIV have been identified in HIV-exposed seronegative (HESN) individuals. The cervicovaginal epithelium has not been studied for such correlates despite constituting an important barrier against sexual HIV transmission. To fill this gap in knowledge, we collected samples of blood and genital mucosa from Kenyan HESN sex workers (n=29) and controls (n=33). The samples were analyzed by several methods including tissue-based RNA sequencing. A significantly higher relative proportion of regulatory T cells and lower proportion of activated cervical T cells were found in the HESN group compared with the controls. However, they had comparable tissue RNA transcriptional profiles. In conclusion, the identification of an increased proportion of regulatory T cells in blood, a lower proportion of activated cervical T cells, and an intact ectocervical microenvironment in HESN individuals add new data to current knowledge about natural resistance to sexual transmission of HIV.

GEO Accession ID: GSE165132

PMID: 33806390

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